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Dr. Mario 64 (Gameplay)

Gameplay

Dr. Mario and Wario face off in Story Mode from Dr. Mario 64.
A screenshot from Dr. Mario 64.

Dr. Mario 64 plays the same as its pre­de­cess­ors for the most part. Dr. Mario throws vitamin capsules into a bottle full of viruses, and the goal is to line up a minimum of four of a color combination of viruses and vitamins to make them disappear. There are three types of Viruses - the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a vitamin color designed to defeat them.

Much like the multiplayer in the previous Dr. Mario games, if a player creates a combo that involves clearing multiple lines in a single move, the opponent will receive up to four garbage pieces depending on how many lines are cleared, and even if more than four lines are cleared, only four garbage pieces will be sent. In any of the 4P modes, the mechanics in which garbage is sent is different. For this mode, the opponent to receive the garbage depends on the first color cleared in a combo, where blue lines will affect the opponent directly to the right, yellow lines affect the opponent two places to the right, and red lines affect the opponent three places to the right. The placement loops back to the left if the placement goes beyond the last player, so for example, 4P will send garbage to 2P if a combo starting with a yellow line is cleared. If two colors are cleared simultaneously for the first part of a combo, two opponents will be affected, depending on which colors are cleared. If any of the players retired for that match, the affected opponent(s) will also change, depending on the aforementioned ordering. For example, if 1P is eliminated and 3P clears a combo starting with a red line, 4P will be affected because 4P is three places to the right instead of 2P, because 1P cannot receive garbage due to being out of the current game. For Team Battle, the system on how the opponents receive garbage is slightly different. The opponent to receive garbage is similar to the standard 4P Vs., but if the affected player is the player's teammate, garbage will be stored as stock, and will only be sent if the affected player is not the player's teammate, where stored garbage is sent in addition to the garbage from the current combo.

Game Modes

One Player

  • Classic: The original Dr. Mario gameplay, where the objective is to eliminate all viruses in the bottle. After the objective is reached, the player goes to the next level which starts with 4 more viruses than the last, for a maximum of 96 viruses.
  • Story: Play through 8 stages as Dr. Mario or Wario in a story about Dr. Mario and the Cold Caper. The amount of viruses and the speed is based on the difficulty. If the player has defeated a specific opponent, they will be able to continue from that specific stage. The player can continue from a stage for that specific character and difficulty if they have reached it with that specific character and difficulty, except for Stage 9, which must be reached normally every time. The S-Hard difficulty can be accessed by highlighting the Hard difficulty and pressing Z Button.
  • Vs. Computer: Compete against a CPU player to either eliminate all the viruses first, or to cause them to lose by stacking up garbage in their bottle.
  • Flash: Compete against a CPU player to eliminate all the flashing viruses, one of each color. The player can also win if their opponent loses by topping up their bottle. The CPU difficulty can be adjusted similarly to the Vs. Computer mode. The amount of viruses (including the flashing viruses) in the Game Lv. for Easy, Normal, Hard are 30, 40, and 50 respectively.
  • Marathon: Viruses will continuously rise from the bottom of the bottle, indicated by if one of the three virus in the magnifying glass revolved and reached the marker. Once a virus reached the marker, a new row of viruses will push the stack up after a capsule is placed. It is possible to force a new row of viruses to be pushed up. If a capsule or virus is pushed up and reached past the top of the bottle, the game is over. If a combo is made, the viruses will temporarily stop moving, delaying the pushing up of the stack. If a specific color of virus disappears from the bottle, the virus in the magnifying glass will disappear but it will not stop the stack from forcibly being pushed up.
  • Score Attack: Within 3 minutes, the player needs to eliminate all the viruses. The remaining time is converted to extra points after eliminating all viruses. If the 3 minutes is up or that the capsules reach the top of bottle, the game is over. The amount of viruses in the Game Lv. for Easy, Normal, Hard are 30, 40, and 50 respectively.

Two Player

To select one of these modes, at least two controllers must be connected, even if they are plugged in slots other than both 1P and 2P, though they will still be registered as 1P and 2P.

  • Two-Player Vs.: Compete against another player to either eliminate all the viruses first, or to cause them to lose by stacking up garbage in their bottle.
  • Flash: Compete against another player to eliminate all the flashing viruses, one of each color. The player can also win if their opponent loses by topping up their bottle. The amount of viruses (including the flashing viruses) in the Game Lv. for Easy, Normal, Hard are 30, 40, and 50 respectively.
  • Score Attack: Within 3 minutes, each player competes for the highest score. Unlike in other Vs. modes, garbage is not sent to the opponent after clearing combos. Even if either player eliminates all viruses or got a game over, the other player can still proceed until they either eliminate all the viruses or get a game over. Once both players cannot continue, the winner is determined by having the most amount of points, where any remaining time is converted to extra points after eliminating all viruses. A draw will occur if the score for both players are the same. The amount of viruses in the Game Lv. for Easy, Normal, Hard are 30, 40, and 50 respectively.

Multiplayer

For Multiplayer, there will always be four players, and if there are less than four human players (including just one player), CPU players will substitute for the other slots.

  • 4P Vs.: Compete against other player to either eliminate all the viruses first, or to cause them to lose by stacking up garbage in their bottle.
  • Team Battle: Together with a partner in teams of 1P/2P and 3P/4P, both teams compete so that one of the players in a team eliminates all viruses, or both players in the opposing team gets a game over.
  • Flash: Compete against other players to eliminate all the flashing viruses, one of each color. The player can also win if their opponents loses by topping up their bottles. The amount of viruses (including the flashing viruses) in the Game Lv. for Easy, Normal, Hard are 30, 40, and 50 respectively.